Left ventricular remodeling is a progressive pathological process by which the size, shape, and function of the ventricle are changed due to myocardial infarction (heart attack), cardiomyopathy, hypertension, or valvular heart disease. The size and location of a myocardial infarction (MI) sets into motion left ventricular remodeling. Ventricular remodeling is commonly seen in patients with moderate to severe ischemic mitral valve regurgitation (MR). The presentation may be either acute or develop insidiously over time in association with congestive heart failure.
Ventricular remodeling is regulated by mechanical, neurohormonal, and genetic factors; however studies have shown that early repair of MR may substantially reverse the otherwise progressive remodeling process.
